The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.
Identifieur interne : 000034 ( Main/Exploration ); précédent : 000033; suivant : 000035The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.
Auteurs : Kanako Miyano [Japon] ; Moeko Eto [Japon] ; Suzuro Hitomi [Japon] ; Takashi Matsumoto [Japon] ; Seiya Hasegawa [Japon] ; Ayane Hirano [Japon] ; Kaori Nagabuchi [Japon] ; Noriho Asai [Japon] ; Miaki Uzu [Japon] ; Miki Nonaka [Japon] ; Yuji Omiya [Japon] ; Atsushi Kaneko [Japon] ; Kentaro Ono [Japon] ; Hideaki Fujii [Japon] ; Yoshikazu Higami [Japon] ; Toru Kono [Japon] ; Yasuhito Uezono [Japon]Source :
- Scientific reports [ 2045-2322 ] ; 2020.
Descripteurs français
- KwdFr :
- Administration par voie orale (MeSH), Animaux (MeSH), Antinéoplasiques (effets indésirables), Cellules cultivées (MeSH), Cicatrisation de plaie (effets des médicaments et des substances chimiques), Gingembre (composition chimique), Glycyrrhiza (composition chimique), Humains (MeSH), Kératinocytes (cytologie), Kératinocytes (effets des médicaments et des substances chimiques), Kératinocytes (métabolisme), Mitogen-Activated Protein Kinase Kinases (métabolisme), Modèles animaux de maladie humaine (MeSH), Mouvement cellulaire (effets des médicaments et des substances chimiques), Médicaments issus de plantes chinoises (administration et posologie), Médicaments issus de plantes chinoises (composition chimique), Médicaments issus de plantes chinoises (pharmacologie), Plantes médicinales (composition chimique), Racines de plante (composition chimique), Rats (MeSH), Récepteurs CXCR4 (métabolisme), Stomatite (induit chimiquement), Stomatite (métabolisme), Stomatite (traitement médicamenteux).
- MESH :
- administration et posologie : Médicaments issus de plantes chinoises.
- composition chimique : Gingembre, Glycyrrhiza, Médicaments issus de plantes chinoises, Plantes médicinales, Racines de plante.
- cytologie : Kératinocytes.
- effets des médicaments et des substances chimiques : Cicatrisation de plaie, Kératinocytes, Mouvement cellulaire.
- effets indésirables : Antinéoplasiques.
- induit chimiquement : Stomatite.
- métabolisme : Kératinocytes, Mitogen-Activated Protein Kinase Kinases, Récepteurs CXCR4, Stomatite.
- pharmacologie : Médicaments issus de plantes chinoises.
- traitement médicamenteux : Stomatite.
- Administration par voie orale, Animaux, Cellules cultivées, Humains, Modèles animaux de maladie humaine, Rats.
English descriptors
- KwdEn :
- Administration, Oral (MeSH), Animals (MeSH), Antineoplastic Agents (adverse effects), Cell Movement (drug effects), Cells, Cultured (MeSH), Disease Models, Animal (MeSH), Drugs, Chinese Herbal (administration & dosage), Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (pharmacology), Ginger (chemistry), Glycyrrhiza (chemistry), Humans (MeSH), Keratinocytes (cytology), Keratinocytes (drug effects), Keratinocytes (metabolism), Mitogen-Activated Protein Kinase Kinases (metabolism), Plant Roots (chemistry), Plants, Medicinal (chemistry), Rats (MeSH), Receptors, CXCR4 (metabolism), Stomatitis (chemically induced), Stomatitis (drug therapy), Stomatitis (metabolism), Wound Healing (drug effects).
- MESH :
- chemical , administration & dosage : Drugs, Chinese Herbal.
- chemical , adverse effects : Antineoplastic Agents.
- chemical , chemistry : Drugs, Chinese Herbal.
- chemically induced : Stomatitis.
- chemistry : Ginger, Glycyrrhiza, Plant Roots, Plants, Medicinal.
- cytology : Keratinocytes.
- drug effects : Cell Movement, Keratinocytes, Wound Healing.
- drug therapy : Stomatitis.
- metabolism : Keratinocytes, Mitogen-Activated Protein Kinase Kinases, Receptors, CXCR4, Stomatitis.
- chemical , pharmacology : Drugs, Chinese Herbal.
- Administration, Oral, Animals, Cells, Cultured, Disease Models, Animal, Humans, Rats.
Abstract
Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased interleukin 1β-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats. However, HST effects on tissue repair functions in HOKs remain unclear. Here, we examined the effects of HST on scratch-induced wound healing in vitro and in vivo. In vitro, HST enhanced wound healing mainly through scratch-induced HOK migration. Screening of the seven constituent medicinal herbs and their major components revealed that Scutellaria root, processed ginger, and Glycyrrhiza components mainly induced the scratch-induced HOK migration. Pharmacokinetic analyses indicated that the active ingredient concentrations in rat plasma following oral HST administration were below the effective doses for HOK migration, suggesting direct effects of HST in OUM. Mitogen-activated protein kinase and C-X-C chemokine receptor 4 inhibitors significantly suppressed HST-induced HOK migration. Moreover, HST enhanced tissue repair in our OUM rat model. Thus, HST likely enhanced OUM tissue repair through oral keratinocyte migration upon MAPK and CXCR4 activation and may be useful in patients with cancer-associated OUM.
DOI: 10.1038/s41598-019-57192-2
PubMed: 31953420
PubMed Central: PMC6969174
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.</title><author><name sortKey="Miyano, Kanako" sort="Miyano, Kanako" uniqKey="Miyano K" first="Kanako" last="Miyano">Kanako Miyano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Eto, Moeko" sort="Eto, Moeko" uniqKey="Eto M" first="Moeko" last="Eto">Moeko Eto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Hitomi, Suzuro" sort="Hitomi, Suzuro" uniqKey="Hitomi S" first="Suzuro" last="Hitomi">Suzuro Hitomi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580</wicri:regionArea><wicri:noRegion>803-8580</wicri:noRegion></affiliation></author><author><name sortKey="Matsumoto, Takashi" sort="Matsumoto, Takashi" uniqKey="Matsumoto T" first="Takashi" last="Matsumoto">Takashi Matsumoto</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Seiya" sort="Hasegawa, Seiya" uniqKey="Hasegawa S" first="Seiya" last="Hasegawa">Seiya Hasegawa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Hirano, Ayane" sort="Hirano, Ayane" uniqKey="Hirano A" first="Ayane" last="Hirano">Ayane Hirano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Nagabuchi, Kaori" sort="Nagabuchi, Kaori" uniqKey="Nagabuchi K" first="Kaori" last="Nagabuchi">Kaori Nagabuchi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Noriho" sort="Asai, Noriho" uniqKey="Asai N" first="Noriho" last="Asai">Noriho Asai</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Uzu, Miaki" sort="Uzu, Miaki" uniqKey="Uzu M" first="Miaki" last="Uzu">Miaki Uzu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Nonaka, Miki" sort="Nonaka, Miki" uniqKey="Nonaka M" first="Miki" last="Nonaka">Miki Nonaka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Omiya, Yuji" sort="Omiya, Yuji" uniqKey="Omiya Y" first="Yuji" last="Omiya">Yuji Omiya</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Kaneko, Atsushi" sort="Kaneko, Atsushi" uniqKey="Kaneko A" first="Atsushi" last="Kaneko">Atsushi Kaneko</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Ono, Kentaro" sort="Ono, Kentaro" uniqKey="Ono K" first="Kentaro" last="Ono">Kentaro Ono</name><affiliation wicri:level="1"><nlm:affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580</wicri:regionArea><wicri:noRegion>803-8580</wicri:noRegion></affiliation></author><author><name sortKey="Fujii, Hideaki" sort="Fujii, Hideaki" uniqKey="Fujii H" first="Hideaki" last="Fujii">Hideaki Fujii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Higami, Yoshikazu" sort="Higami, Yoshikazu" uniqKey="Higami Y" first="Yoshikazu" last="Higami">Yoshikazu Higami</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Kono, Toru" sort="Kono, Toru" uniqKey="Kono T" first="Toru" last="Kono">Toru Kono</name><affiliation wicri:level="1"><nlm:affiliation>Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido</wicri:regionArea><wicri:noRegion>Hokkaido</wicri:noRegion></affiliation></author><author><name sortKey="Uezono, Yasuhito" sort="Uezono, Yasuhito" uniqKey="Uezono Y" first="Yasuhito" last="Uezono">Yasuhito Uezono</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31953420</idno><idno type="pmid">31953420</idno><idno type="doi">10.1038/s41598-019-57192-2</idno><idno type="pmc">PMC6969174</idno><idno type="wicri:Area/Main/Corpus">000247</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000247</idno><idno type="wicri:Area/Main/Curation">000247</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000247</idno><idno type="wicri:Area/Main/Exploration">000247</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.</title><author><name sortKey="Miyano, Kanako" sort="Miyano, Kanako" uniqKey="Miyano K" first="Kanako" last="Miyano">Kanako Miyano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Eto, Moeko" sort="Eto, Moeko" uniqKey="Eto M" first="Moeko" last="Eto">Moeko Eto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Hitomi, Suzuro" sort="Hitomi, Suzuro" uniqKey="Hitomi S" first="Suzuro" last="Hitomi">Suzuro Hitomi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580</wicri:regionArea><wicri:noRegion>803-8580</wicri:noRegion></affiliation></author><author><name sortKey="Matsumoto, Takashi" sort="Matsumoto, Takashi" uniqKey="Matsumoto T" first="Takashi" last="Matsumoto">Takashi Matsumoto</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Seiya" sort="Hasegawa, Seiya" uniqKey="Hasegawa S" first="Seiya" last="Hasegawa">Seiya Hasegawa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Hirano, Ayane" sort="Hirano, Ayane" uniqKey="Hirano A" first="Ayane" last="Hirano">Ayane Hirano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Nagabuchi, Kaori" sort="Nagabuchi, Kaori" uniqKey="Nagabuchi K" first="Kaori" last="Nagabuchi">Kaori Nagabuchi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Noriho" sort="Asai, Noriho" uniqKey="Asai N" first="Noriho" last="Asai">Noriho Asai</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Uzu, Miaki" sort="Uzu, Miaki" uniqKey="Uzu M" first="Miaki" last="Uzu">Miaki Uzu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Nonaka, Miki" sort="Nonaka, Miki" uniqKey="Nonaka M" first="Miki" last="Nonaka">Miki Nonaka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author><author><name sortKey="Omiya, Yuji" sort="Omiya, Yuji" uniqKey="Omiya Y" first="Yuji" last="Omiya">Yuji Omiya</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Kaneko, Atsushi" sort="Kaneko, Atsushi" uniqKey="Kaneko A" first="Atsushi" last="Kaneko">Atsushi Kaneko</name><affiliation wicri:level="1"><nlm:affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192</wicri:regionArea><wicri:noRegion>300-1192</wicri:noRegion></affiliation></author><author><name sortKey="Ono, Kentaro" sort="Ono, Kentaro" uniqKey="Ono K" first="Kentaro" last="Ono">Kentaro Ono</name><affiliation wicri:level="1"><nlm:affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580</wicri:regionArea><wicri:noRegion>803-8580</wicri:noRegion></affiliation></author><author><name sortKey="Fujii, Hideaki" sort="Fujii, Hideaki" uniqKey="Fujii H" first="Hideaki" last="Fujii">Hideaki Fujii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641</wicri:regionArea><wicri:noRegion>108-8641</wicri:noRegion></affiliation></author><author><name sortKey="Higami, Yoshikazu" sort="Higami, Yoshikazu" uniqKey="Higami Y" first="Yoshikazu" last="Higami">Yoshikazu Higami</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, 278-8510</wicri:regionArea><wicri:noRegion>278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Kono, Toru" sort="Kono, Toru" uniqKey="Kono T" first="Toru" last="Kono">Toru Kono</name><affiliation wicri:level="1"><nlm:affiliation>Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido</wicri:regionArea><wicri:noRegion>Hokkaido</wicri:noRegion></affiliation></author><author><name sortKey="Uezono, Yasuhito" sort="Uezono, Yasuhito" uniqKey="Uezono Y" first="Yasuhito" last="Uezono">Yasuhito Uezono</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045</wicri:regionArea><wicri:noRegion>104-0045</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral (MeSH)</term><term>Animals (MeSH)</term><term>Antineoplastic Agents (adverse effects)</term><term>Cell Movement (drug effects)</term><term>Cells, Cultured (MeSH)</term><term>Disease Models, Animal (MeSH)</term><term>Drugs, Chinese Herbal (administration & dosage)</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Ginger (chemistry)</term><term>Glycyrrhiza (chemistry)</term><term>Humans (MeSH)</term><term>Keratinocytes (cytology)</term><term>Keratinocytes (drug effects)</term><term>Keratinocytes (metabolism)</term><term>Mitogen-Activated Protein Kinase Kinases (metabolism)</term><term>Plant Roots (chemistry)</term><term>Plants, Medicinal (chemistry)</term><term>Rats (MeSH)</term><term>Receptors, CXCR4 (metabolism)</term><term>Stomatitis (chemically induced)</term><term>Stomatitis (drug therapy)</term><term>Stomatitis (metabolism)</term><term>Wound Healing (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale (MeSH)</term><term>Animaux (MeSH)</term><term>Antinéoplasiques (effets indésirables)</term><term>Cellules cultivées (MeSH)</term><term>Cicatrisation de plaie (effets des médicaments et des substances chimiques)</term><term>Gingembre (composition chimique)</term><term>Glycyrrhiza (composition chimique)</term><term>Humains (MeSH)</term><term>Kératinocytes (cytologie)</term><term>Kératinocytes (effets des médicaments et des substances chimiques)</term><term>Kératinocytes (métabolisme)</term><term>Mitogen-Activated Protein Kinase Kinases (métabolisme)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Mouvement cellulaire (effets des médicaments et des substances chimiques)</term><term>Médicaments issus de plantes chinoises (administration et posologie)</term><term>Médicaments issus de plantes chinoises (composition chimique)</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Plantes médicinales (composition chimique)</term><term>Racines de plante (composition chimique)</term><term>Rats (MeSH)</term><term>Récepteurs CXCR4 (métabolisme)</term><term>Stomatite (induit chimiquement)</term><term>Stomatite (métabolisme)</term><term>Stomatite (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Stomatitis</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ginger</term><term>Glycyrrhiza</term><term>Plant Roots</term><term>Plants, Medicinal</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Gingembre</term><term>Glycyrrhiza</term><term>Médicaments issus de plantes chinoises</term><term>Plantes médicinales</term><term>Racines de plante</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Kératinocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Keratinocytes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Movement</term><term>Keratinocytes</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stomatitis</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cicatrisation de plaie</term><term>Kératinocytes</term><term>Mouvement cellulaire</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Stomatite</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Keratinocytes</term><term>Mitogen-Activated Protein Kinase Kinases</term><term>Receptors, CXCR4</term><term>Stomatitis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Kératinocytes</term><term>Mitogen-Activated Protein Kinase Kinases</term><term>Récepteurs CXCR4</term><term>Stomatite</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Stomatite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Humans</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Cellules cultivées</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased interleukin 1β-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats. However, HST effects on tissue repair functions in HOKs remain unclear. Here, we examined the effects of HST on scratch-induced wound healing in vitro and in vivo. In vitro, HST enhanced wound healing mainly through scratch-induced HOK migration. Screening of the seven constituent medicinal herbs and their major components revealed that Scutellaria root, processed ginger, and Glycyrrhiza components mainly induced the scratch-induced HOK migration. Pharmacokinetic analyses indicated that the active ingredient concentrations in rat plasma following oral HST administration were below the effective doses for HOK migration, suggesting direct effects of HST in OUM. Mitogen-activated protein kinase and C-X-C chemokine receptor 4 inhibitors significantly suppressed HST-induced HOK migration. Moreover, HST enhanced tissue repair in our OUM rat model. Thus, HST likely enhanced OUM tissue repair through oral keratinocyte migration upon MAPK and CXCR4 activation and may be useful in patients with cancer-associated OUM.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31953420</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>01</Month><Day>17</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.</ArticleTitle><Pagination><MedlinePgn>625</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-019-57192-2</ELocationID><Abstract><AbstractText>Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased interleukin 1β-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats. However, HST effects on tissue repair functions in HOKs remain unclear. Here, we examined the effects of HST on scratch-induced wound healing in vitro and in vivo. In vitro, HST enhanced wound healing mainly through scratch-induced HOK migration. Screening of the seven constituent medicinal herbs and their major components revealed that Scutellaria root, processed ginger, and Glycyrrhiza components mainly induced the scratch-induced HOK migration. Pharmacokinetic analyses indicated that the active ingredient concentrations in rat plasma following oral HST administration were below the effective doses for HOK migration, suggesting direct effects of HST in OUM. Mitogen-activated protein kinase and C-X-C chemokine receptor 4 inhibitors significantly suppressed HST-induced HOK migration. Moreover, HST enhanced tissue repair in our OUM rat model. Thus, HST likely enhanced OUM tissue repair through oral keratinocyte migration upon MAPK and CXCR4 activation and may be useful in patients with cancer-associated OUM.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miyano</LastName><ForeName>Kanako</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eto</LastName><ForeName>Moeko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hitomi</LastName><ForeName>Suzuro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2653-5372</Identifier><AffiliationInfo><Affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasegawa</LastName><ForeName>Seiya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hirano</LastName><ForeName>Ayane</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagabuchi</LastName><ForeName>Kaori</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asai</LastName><ForeName>Noriho</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uzu</LastName><ForeName>Miaki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nonaka</LastName><ForeName>Miki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Omiya</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaneko</LastName><ForeName>Atsushi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, 300-1192, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ono</LastName><ForeName>Kentaro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Physiology, Kyushu Dental University, Fukuoka, 803-8580, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fujii</LastName><ForeName>Hideaki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, 108-8641, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Higami</LastName><ForeName>Yoshikazu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278-8510, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, 278-8510, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kono</LastName><ForeName>Toru</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uezono</LastName><ForeName>Yasuhito</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045, Japan. yuezono@ncc.go.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C527276">CXCR4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019718">Receptors, CXCR4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C088236">hange-shashinto</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.12.2</RegistryNumber><NameOfSubstance UI="D020929">Mitogen-Activated Protein Kinase Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Sci Rep. 2020 Nov 9;10(1):19806</RefSource><PMID Version="1">33168924</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020939" MajorTopicYN="N">Ginger</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006035" MajorTopicYN="N">Glycyrrhiza</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020929" MajorTopicYN="N">Mitogen-Activated Protein Kinase Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019718" MajorTopicYN="N">Receptors, CXCR4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013280" MajorTopicYN="N">Stomatitis</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>12</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31953420</ArticleId><ArticleId IdType="doi">10.1038/s41598-019-57192-2</ArticleId><ArticleId IdType="pii">10.1038/s41598-019-57192-2</ArticleId><ArticleId IdType="pmc">PMC6969174</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Miyano, Kanako" sort="Miyano, Kanako" uniqKey="Miyano K" first="Kanako" last="Miyano">Kanako Miyano</name></noRegion><name sortKey="Asai, Noriho" sort="Asai, Noriho" uniqKey="Asai N" first="Noriho" last="Asai">Noriho Asai</name><name sortKey="Asai, Noriho" sort="Asai, Noriho" uniqKey="Asai N" first="Noriho" last="Asai">Noriho Asai</name><name sortKey="Eto, Moeko" sort="Eto, Moeko" uniqKey="Eto M" first="Moeko" last="Eto">Moeko Eto</name><name sortKey="Eto, Moeko" sort="Eto, Moeko" uniqKey="Eto M" first="Moeko" last="Eto">Moeko Eto</name><name sortKey="Fujii, Hideaki" sort="Fujii, Hideaki" uniqKey="Fujii H" first="Hideaki" last="Fujii">Hideaki Fujii</name><name sortKey="Hasegawa, Seiya" sort="Hasegawa, Seiya" uniqKey="Hasegawa S" first="Seiya" last="Hasegawa">Seiya Hasegawa</name><name sortKey="Hasegawa, Seiya" sort="Hasegawa, Seiya" uniqKey="Hasegawa S" first="Seiya" last="Hasegawa">Seiya Hasegawa</name><name sortKey="Higami, Yoshikazu" sort="Higami, Yoshikazu" uniqKey="Higami Y" first="Yoshikazu" last="Higami">Yoshikazu Higami</name><name sortKey="Higami, Yoshikazu" sort="Higami, Yoshikazu" uniqKey="Higami Y" first="Yoshikazu" last="Higami">Yoshikazu Higami</name><name sortKey="Hirano, Ayane" sort="Hirano, Ayane" uniqKey="Hirano A" first="Ayane" last="Hirano">Ayane Hirano</name><name sortKey="Hirano, Ayane" sort="Hirano, Ayane" uniqKey="Hirano A" first="Ayane" last="Hirano">Ayane Hirano</name><name sortKey="Hitomi, Suzuro" sort="Hitomi, Suzuro" uniqKey="Hitomi S" first="Suzuro" last="Hitomi">Suzuro Hitomi</name><name sortKey="Kaneko, Atsushi" sort="Kaneko, Atsushi" uniqKey="Kaneko A" first="Atsushi" last="Kaneko">Atsushi Kaneko</name><name sortKey="Kono, Toru" sort="Kono, Toru" uniqKey="Kono T" first="Toru" last="Kono">Toru Kono</name><name sortKey="Matsumoto, Takashi" sort="Matsumoto, Takashi" uniqKey="Matsumoto T" first="Takashi" last="Matsumoto">Takashi Matsumoto</name><name sortKey="Nagabuchi, Kaori" sort="Nagabuchi, Kaori" uniqKey="Nagabuchi K" first="Kaori" last="Nagabuchi">Kaori Nagabuchi</name><name sortKey="Nagabuchi, Kaori" sort="Nagabuchi, Kaori" uniqKey="Nagabuchi K" first="Kaori" last="Nagabuchi">Kaori Nagabuchi</name><name sortKey="Nonaka, Miki" sort="Nonaka, Miki" uniqKey="Nonaka M" first="Miki" last="Nonaka">Miki Nonaka</name><name sortKey="Omiya, Yuji" sort="Omiya, Yuji" uniqKey="Omiya Y" first="Yuji" last="Omiya">Yuji Omiya</name><name sortKey="Ono, Kentaro" sort="Ono, Kentaro" uniqKey="Ono K" first="Kentaro" last="Ono">Kentaro Ono</name><name sortKey="Uezono, Yasuhito" sort="Uezono, Yasuhito" uniqKey="Uezono Y" first="Yasuhito" last="Uezono">Yasuhito Uezono</name><name sortKey="Uezono, Yasuhito" sort="Uezono, Yasuhito" uniqKey="Uezono Y" first="Yasuhito" last="Uezono">Yasuhito Uezono</name><name sortKey="Uezono, Yasuhito" sort="Uezono, Yasuhito" uniqKey="Uezono Y" first="Yasuhito" last="Uezono">Yasuhito Uezono</name><name sortKey="Uzu, Miaki" sort="Uzu, Miaki" uniqKey="Uzu M" first="Miaki" last="Uzu">Miaki Uzu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000034 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000034 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PlantImRecepV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31953420
|texte= The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31953420" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PlantImRecepV1
| This area was generated with Dilib version V0.6.38. |  |